APOBEC3G

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APOBEC3G is a human protein that interferes with the replication of HIV. It was first identified by Ann Sheehy in 2002 as a cellular factor able to restrict replication of HIV-1 lacking the viral accessory protein Vif. Soon after, it was shown that APOBEC3G belonged to a family of proteins grouped together due to their homology with the cytidine deaminase APOBEC1. APOBEC3G is able to act as a cytidine deaminase, inducing mutations in the HIV DNA. However, it is also able to function as anti-viral protein when the catalytic sites have been mutated (and it can no longer mutate viral DNA). The mechanism of this activity remains largely unknown.

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