Arrhenoblastoma

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The arrhenoblastoma is a rare ovarian stromal neoplasm that secretes testosterone. While it may occur at any age, it is mostly seen in women in the reproductive years. Typically it is unilateral.

The key clinical features of this tumor are related to its endocrine activity. The excessive production of testosterone leads to progressive masculinization in a woman who typically had been normal. Thus the person may experience not only anovulation and amenorrhea, but usually also acne and hirsutism, voice deepening, clitoromegaly, temporal hair recession, and an increase in musculature. On gynecologic ultrasonography a unilateral solid lesion can be seen in the ovary. A serum testosterone level is high.

The treatment consists of surgical removal and the prognosis is generally good as the lesion tends to grow slowly and rarely metastasizes.

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