Ataxia telangiectasia mutated
Encyclopedia : A : AT : ATA : Ataxia telangiectasia mutated
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| align="center" colspan="2" |
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| colspan="2" bgcolor="#dddddd" | Identifiers
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| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [ATM ] ATA; ATDC; TEL1
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| bgcolor="#e7dcc3" | Entrez
| bgcolor="#eeeeee" | [472 ]
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | OMIM
| bgcolor="#eeeeee" | [607585 ]
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| bgcolor="#e7dcc3" | RefSeq
| bgcolor="#eeeeee" | [NM_138293 ]
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| bgcolor="#e7dcc3" | UniProt
| bgcolor="#eeeeee" | [Q13315 ]
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | PDB
| bgcolor="#eeeeee" | [Other data
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | EC number
| bgcolor="#eeeeee" | [2.7.1.37 ]
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| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | Chr. 11 [q22-23 ]
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Ataxia-telangiectasia mutated (ATM) is a serine /threonine -specific protein kinase that is recruited and activated by double stranded breaks of DNA and the MRN complex. It phosphorylates several key proteins that initiate cell cycle arrest, DNA repair or apoptosis . Several of these targets, including TP53 , CHEK2, BRCA1 , and H2AFX are tumor suppressors.
External links
http://www.hprd.org/protein/06347
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