Avian flu
Encyclopedia : A : AV : AVI : Avian flu
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All known avian flu viruses belong to the species of virus called Influenza A virus. All subtypes (but not all strains of all subtypes) of Influenza A virus are adapted to birds, which is why for many purposes avian flu virus is the Influenza A virus (note that the "A" does not stand for "avian").
As of 2006, "avian flu" is being commonly used to refer to infection from a particular subtype of Influenza A virus, H5N1, which is currently the world's major flu pandemic threat.
Avian flu viruses are noninfectious for most species. When they are infectious they are usually asymptomatic, so the carrier does not have any disease from it. Thus while infected with an avian flu virus, the animal doesn't have a "flu". Typically, when illness (called "flu") from an avian flu virus does occur, it is the result of an avian flu virus strain adapted to one species spreading to another species (usually from one bird species to another bird species). So far as we know the most common result of this is an illness so minor as to be not worth noticing (and thus little studied). But with the domestication of chickens and turkeys, we have created species subtypes (domesticated poultry) that can catch an avian flu virus adapted to waterfowl and have it rapidly mutate into a form that kills in days over 90% of an entire flock and spread to other flocks and kill 90% of them and can only be stopped by killing every domestic bird in the area. Until H5N1, this was basically the whole story of avian flu so far as anyone knew or cared (outside of the poultry industry). Now with H5N1, we have a whole new ballgame with H5N1 inventing new rules as it goes with behaviors never noticed before, and possibly never having occurred before. This is evolution right before our eyes. Even the Spanish flu virus did not behave like this. What is worth mentioning about illness from avian flu viruses is covered in H5N1 flu, Flu, and the subtype articles (H5N1, HxNy) linked below (and the references in those articles).
A few examples of correct and incorrect usage of the term "avian flu" itself follow. For more scientific information about avian flu, see the subtype links towards the bottom of this article, H5N1 flu, Flu, Influenzavirus A, and other linked articles.
Illustrative examples of correct usage
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| WHO pandemic phases 1. Low risk 2. New virus 3. Self limiting 4. Person to person 5. Epidemic exists 6. Pandemic exists |
In technical contexts, correct usage of terms is necessary because precise distinctions are the essence of the communication.
- "Avian influenza strains are those well adapted to birds"
- "An outbreak of influenza A (H5N1), also known as 'avian flu' or 'bird flu,' has been reported in several countries throughout Asia." [OSHA]
- "Avian influenza virus usually refers to influenza A viruses found chiefly in birds, but infections can occur in humans." [CDC] Avian Influenza (Bird Flu)
- "Of the few avian influenza viruses that have crossed the species barrier to infect humans, H5N1 has caused the largest number of cases of severe disease and death in humans. Unlike normal seasonal influenza, where infection causes only mild respiratory symptoms in most people, the disease caused by H5N1 follows an unusually aggressive clinical course, with rapid deterioration and high fatality." Seasonal influenza is human flu. [WHO] Avian influenza frequently asked questions
- "avian influenza HA bind alpha 2-3 sialic acid receptors while human influenza HA bind alpha 2-6 sialic acid receptors. Swine influenza viruses have the ability to bind both types of sialic acid receptors." [Greninger Paper (PDF)]
- Sometimes a virus contains both avian adapted genes and human adapted genes. Both the H2N2 and H3N2 pandemic strains contained avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005)."
Illustrative examples of imprecise usage
In nontechnical contexts, imprecise usage of terms is typical when discussing complex things.
- "A 1,000 square mile quarantine zone to combat an outbreak of bird flu was lifted in Scotland today - despite the spread of a similar disease south of the border." Here "bird flu" is used to mean "Asian lineage HPAI A(H5N1) flu" (which is a bird flu) and contrasted with flu from an avian adapted strain of H7N3 (which is also a bird flu). (Click the links for details.) [News] Avian flu quarantine zone lifted published May 1, 2006.
See also
- Timeline data on avian flu
- Timeline data on avian flu can be found at the article on the causative agent species called Influenza A virus.
- Timeline data on the global spread of the strain that is the current pandemic concern (called Asian lineage HPAI A(H5N1)) can be found at Global spread of H5N1.
- Timeline data on creation of a flu vaccine for H5N1 can be found at H5N1 clinical trials.
- Center for Biologics Evaluation and Research
- Flu research
- Flu vaccine
- H5N1 genetic structure
- ICEID
- Influenza Genome Sequencing Project
- Influenza pandemic
- Cytokine storm
- International Partnership on Avian and Pandemic Influenza
- National Influenza Centers
- Pandemic Preparedness and Response Act
- Reporting disease cases
- Transmission and infection of H5N1
Sources and notes
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