B7 (protein)
Encyclopedia : B : B7 : B7P : B7 (protein)
B7 is a type of peripheral membrane protein found on activated antigen presenting cells (APC) that, when paired with either a CD28 or CD152 (CTLA-4) surface protein on a T cell, can produce a costimulatory signal to enhance the activity of a MHC-TCR signal between the APC and the T cell. (Coico et al. 2003)
There are two major types of B7 proteins, B7.1 and B7.2 or CD80 and CD86 respectively, however it is not known if they differ significantly.
Reference
- Coico, R., Sunshine, G., and Benjamin, E. (2003). “Immunology: A Short Course 5th ed.” Pg. 131.
From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.