Calreticulin
Encyclopedia : C : CA : CAL : Calreticulin
Calreticulin is a protein that binds Ca2+ ions (a second messenger molecule in signal transduction), rendering it inactive. The Ca2+ is bound with low affinity, but high capacity, and can be released on a signal (see inositol triphosphate). Calreticulin is located in storage compartments associated with the endoplasmic reticulum.
Calreticulin is also known as calregulin, CRP55, CaBP3, calsequestrin-like protein and Ro/SS-A antigen.
Calreticulin binds to misfolded protiens and prevents them from being exported from the Endoplasmic Reticulum to the Golgi Apparatus.
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