Central serous retinopathy

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Central serous retinopathy (CSR), also known as central serous chorioretinopathy (CSC), is a visual impairment, often temporary, usually in one eye, affecting males in the age group 20 to 50. The disorder is characterized by leakage of fluid in the central macula, which results in blurred or distorted vision (metamorphopsia). A blind or gray spot in the central vision is common, along with flashes of light (photopsia).

Contents

1 Diagnosis
2 Causes
3 Prognosis
4 Treatment
5 References
6 See also
7 External links

Diagnosis

The diagnosis usually starts with a dilated examination of the retina, followed with confirmation by fluorescein angiography. The angiography test will usually show one or more fluorescent spots with fluid leakage. In 10%-15% of the cases these will appear in a "classic" smoke stack shape. An Amsler grid may be useful in documenting the precise area of the visual field involved.

Causes

CSR is a fluid detachment of macula layers from their supporting tissue. This allows choroidal fluid to leak into the subretinal space. The buildup of fluid seems to occur because of small breaks in the retinal pigment epithelium.

CSR is sometimes called idiopathic CSR which means that its cause is unknown. Nevertheless, stress appears to play an important role. Persons in stressful occupations, such as airplane pilots, have a higher incidence of CSR. The "type A personality" has also been linked to this condition.

CSR has also been associated with cortisol, i.e. people who suffer from CSR have higher levels of cortisol than normal, and persons with higher levels of cortisol than normal also have a higher propensity to suffer from CSR. Cortisol is a hormone secreted by the adrenal cortex which allows the body to deal with stress, which may explain the CSR-stress association. There is extensive evidence to the effect that corticosteroids ("cortisone") --- commonly used to treat inflamations, allergies, skin conditions and even certain eye conditions --- can trigger CSR, aggravate it and cause relapses [link][link][link][link].

The incidence of CSR in persons with Cushing's syndrome is 5%. Cushing's syndrome is characterized by very high cortisol levels.

Recently found evidence has also implicated Helicobacter pylori (see gastritis) as playing a role [link][link]. It would appear that the presence of the bacteria is well correlated with visual acuity and other retinal findings following an attack.

Prognosis

Most patients recover normal vision without treatment in three or four months. Some visual abnormalities can remain even if visual acuity is measured at 20/20. Lasting problems can include decreased night vision, color discrimination problems, and some distortion [link]. About 50% of the patients get the severe and extensive form of the disease after 12 years of evolution. Long term complications can include subretinal neovascularization and pigment epitheliopathy [link].

Treatment

There is no known effective treatment for the disease. Laser photocoagulation, which effectively burns the leak area shut, is sometimes suggested. In many cases the leak is very near the central macula, where photocoagulation would leave a blind spot. Additionally, a better long term outcome has not been demonstrated with photocoagulation. So more often than not the condition goes untreated.

Transpupillary thermotherapy has been suggested as a lower-risk alternative to laser photocoagulation in cases where the leak is in the central macula [link].

Any ongoing corticosteroid treatment should be stopped. Additonally, a new anti-microbial treatment will likely be recommended soon in light of recent findings regarding Helicobacter pylori.

CSR sufferers usually find their own ways to manage the condition, which may include stress reduction and changes in nutrition (see, for example, [link]).

References

The Wills Eye Manual: Office and Emergency Room Diagnosis and Treatment of Eye Disease, J.B. Lippincott, 1994.

External links

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