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Cholestasis

Encyclopedia : C : CH : CHO : Cholestasis

In medicine, cholestasis is a condition where bile cannot flow from the liver to the duodenum.

Contents

1 Etiology
2 Symptoms
3 See also
4 External links

Etiology

gallstones
abdominal mass (e.g. cancer)
primary sclerosing cholangitis, secondary to inflammatory bowel disease
Primary biliary cirrhosis, secondary to autoimmune disorders
congential anomalies of the bilary tract
biliary trauma
some drugs, (e.g. Flucloxacillin and Erythromycin)
in children, biliary atresia and other pediatric liver diseases

Symptoms

Pale stools,
dark urine,
itchiness (pruritus) and
jaundice.

Bile is secreted by the liver to aid in the digestion of fats. Drugs such as gold salts,nitrofurantoin, anabolic steroids, chlorpromazine, prochlorperazine, sulindac, cimetidine, erythromycin, can cause cholestasis and may result in damage to the liver.

See also

Liver function tests
Lipoprotein-X - an abnormal low density lipoprotein found in cholestasis

External links

[Drug-induced cholestasis] - medlineplus.org
[Cholestasis] - emedicine.com
[Liver Families] = pediatric liver support group

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