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<h1>Cytochrome c oxidase</h1>
<p><a href="http://encycl.opentopia.com/">Encyclopedia</a> : <a href="http://encycl.opentopia.com/C">C</a> : <a href="http://encycl.opentopia.com/C/CY">CY</a> : <a href="http://encycl.opentopia.com/C/CY/CYT">CYT</a> : Cytochrome c oxidase</p>
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Cytochrome c oxidase</div>
</div>
</div><p>

<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2265" target="_blank">COX4I1</a>&#093; COX4
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1327&rn=1" target="_blank">1327</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123864&rn=1" target="_blank">123864</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001861&rn=1" target="_blank">NM_001861</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P13073" target="_blank">P13073</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_16_(human)">Chr. 16</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=16q22" target="_blank">q22-qter</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2267" target="_blank">COX5A</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=9377&rn=1" target="_blank">9377</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603773&rn=1" target="_blank">603773</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_004255&rn=1" target="_blank">NM_004255</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P20674" target="_blank">P20674</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_15_(human)">Chr. 15</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=15q25" target="_blank">q25</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2269" target="_blank">COX5B</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1329&rn=1" target="_blank">1329</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123866&rn=1" target="_blank">123866</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001862&rn=1" target="_blank">NM_001862</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P10606" target="_blank">P10606</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_2_(human)">Chr. 2</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=2" target="_blank">cen-q13</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2277" target="_blank">COX6A1</a>&#093; COX6A
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1337&rn=1" target="_blank">1337</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602072&rn=1" target="_blank">602072</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_004373&rn=1" target="_blank">NM_004373</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P12074" target="_blank">P12074</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_12_(human)">Chr. 12</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=12q24" target="_blank">q24</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2279" target="_blank">COX6A2</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1339&rn=1" target="_blank">1339</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=602009&rn=1" target="_blank">602009</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_005205&rn=1" target="_blank">NM_005205</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?Q02221" target="_blank">Q02221</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_16_(human)">Chr. 16</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=16p11.12" target="_blank">p11.12</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2287" target="_blank">COX7A1</a>&#093; COX7A
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1346&rn=1" target="_blank">1346</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123995&rn=1" target="_blank">123995</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001864&rn=1" target="_blank">NM_001864</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P24310" target="_blank">P24310</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_19_(human)">Chr. 19</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=19q13.1" target="_blank">q13.1</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2288" target="_blank">COX7A2</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1347&rn=1" target="_blank">1347</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123996&rn=1" target="_blank">123996</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001865&rn=1" target="_blank">NM_001865</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P14406" target="_blank">P14406</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_6_(human)">Chr. 6</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=6q14.1" target="_blank">q14.1</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2291" target="_blank">COX7B</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1349&rn=1" target="_blank">1349</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603792&rn=1" target="_blank">603792</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001866&rn=1" target="_blank">NM_001866</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P24311" target="_blank">P24311</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_X_(human)">Chr. X</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=Xq21.1" target="_blank">q21.1</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2292" target="_blank">COX7C</a>&#093; 
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1350&rn=1" target="_blank">1350</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=603774&rn=1" target="_blank">603774</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_001867&rn=1" target="_blank">NM_001867</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P15954" target="_blank">P15954</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_5_(human)">Chr. 5</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=5q14" target="_blank">q14</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:2294" target="_blank">COX8A</a>&#093; COX8
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=1351&rn=1" target="_blank">1351</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=123870&rn=1" target="_blank">123870</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=NM_004074&rn=1" target="_blank">NM_004074</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P10176" target="_blank">P10176</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_11_(human)">Chr. 11</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=11q12" target="_blank">q12-q13</a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:7419" target="_blank">MT-CO1</a>&#093; MTCO1
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=4512&rn=1" target="_blank">4512</a>&#093;
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| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=516030&rn=1" target="_blank">516030</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=&rn=1" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?" target="_blank"></a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_mitochondria_(human)">Chr. mitochondria</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=mitochondria" target="_blank"></a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:7421" target="_blank">MT-CO2</a>&#093; MTCO2
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=4513&rn=1" target="_blank">4513</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=516040&rn=1" target="_blank">516040</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=&rn=1" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?P00403" target="_blank">P00403</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_mitochondria_(human)">Chr. mitochondria</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=mitochondria" target="_blank"></a>&#093;</em>
|-
|}
<table   id="drugInfoBox" style="float: right; clear: right; margin: 0 0 0.5em 1em; background: #ffffff;" class="toccolours" border=0 cellpadding=0 align=right width="260px"><tr  class="hiddenStructure"
| colspan="2" |<small></small>
|-
| align="center" colspan="2" | <div style="font-size:medium; line-height:167%;"></div>
|-
| colspan="2" bgcolor="#dddddd" | <strong>Identifiers</strong> 
|-
| bgcolor="#e7dcc3" | <a href="/term/HUGO">Symbol(s)</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.gene.ucl.ac.uk/nomenclature/data/get_data.php?hgnc_id=HGNC:7422" target="_blank">MT-CO3</a>&#093; MTCO3
|-
| bgcolor="#e7dcc3" | <a href="/term/Entrez">Entrez</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=gene&amp;cmd=retrieve&amp;dopt=default&amp;list_uids=4514&rn=1" target="_blank">4514</a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/OMIM">OMIM</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=516050&rn=1" target="_blank">516050</a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/NCBI">RefSeq</a>
| bgcolor="#eeeeee" | &#091;<a href="http://genome.cse.ucsc.edu/cgi-bin/hgGene?org=Human&amp;hgg_gene=&rn=1" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Swiss-Prot">UniProt</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/niceprot.pl?" target="_blank"></a>&#093;
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/Protein_Data_Bank">PDB</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.pdb.org/pdb/cgi/explore.cgi?pdbId=" target="_blank"></a>&#093;
|-
| colspan="2" bgcolor="#dddddd" | <strong>Other data</strong>
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | <a href="/term/EC_number">EC number</a>
| bgcolor="#eeeeee" | &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?" target="_blank"></a>&#093;
|-
| bgcolor="#e7dcc3" | <a href="/term/Locus_(genetics)">Locus</a> 
| bgcolor="#eeeeee" | <a href="/term/Chromosome_mitochondria_(human)">Chr. mitochondria</a> <em>&#091;<a href="http://www.ncbi.nlm.nih.gov/Omim/getmap.cgi?chromosome=mitochondria" target="_blank"></a>&#093;</em>
|-
|}
The <a href="/term/Enzyme">enzyme</a> <strong>cytochrome c oxidase</strong> (<a href="/term/Protein_Data_Bank">PDB</a> &#091;<a href="http://www.rcsb.org/pdb/cgi/explore.cgi?pdbId=2OCC" target="_blank">2OCC</a>&#093;, <a href="/term/EC_number">EC</a> &#091;<a href="http://www.expasy.org/cgi-bin/nicezyme.pl?1.9.3.1" target="_blank">1.9.3.1</a>&#093;<!--fr:Modèle:N° EC-->) is a large transmembrane <a href="/term/Protein">protein</a> found in the <a href="/term/Mitochondrion">mitochondrion</a> and is the terminal electron acceptor in the <a href="/term/Electron_transport_chain">electron transport chain</a> (complex IV), taking 4 reducing equivalents from <a href="/term/Cytochrome_c">cytochrome c</a> and converting molecular <a href="/term/Oxygen">oxygen</a> to water. In the process, it translocates protons, helping to establish a <a href="/term/Chemiosmotic_potential">chemiosmotic potential</a> that the <a href="/term/ATP_synthase">ATP synthase</a> then uses to synthesize <a href="/term/Adenosine_triphosphate">ATP</a>.<p>

Summary reaction:<p>

4 Fe<sup>2+</sup>-cytochrome c + 4H<sup>+</sup> + O<sub>2</sub> &rarr; 4 Fe<sup>3+</sup>-cytochrome c + 2 H<sub>2</sub>O.<p>

The complex is a large <a href="/term/Lipoprotein">lipoprotein</a> composed of several <a href="/term/Metal">metal</a> prosthetic sites and 13 protein subunits. In mammals, 10 subunits are nuclear in origin and 3 are synthesized mitochondrially. The complex contains 2 <a href="/term/Cytochrome">cytochrome</a>s, the a and a<sub>3</sub> cytochromes, and two <a href="/term/Copper">copper</a> centers, the Cu<sub>A</sub> and Cu<sub>B</sub> centers. In fact, the cytochrome a<sub>3</sub> and Cu<sub>B</sub> are a binuclear center that is the site of oxygen reduction. The mechanism of action of this large complex is still an active research topic.<p>

<a href="/term/Cyanide">Cyanide</a>, <a href="/term/Carbon_monoxide">carbon monoxide</a> and <a href="/term/Azide">azide</a> all bind irreversibly to Cytochrome c Oxidase. The protein is then inhibited from functioning, causing chemical <a href="/term/Suffocation">suffocation</a>.<p>

<a name="External_links" id="External_links"></a><h2>External links</h2>
<ul><li>&#091;<a href="http://www-bioc.rice.edu/~graham/CcO.html" target="_blank">The Cytochrome Oxidase home page</a>&#093;</li><li>&#091;<a href="http://www.ufp.pt/~pedros/anim/2frame-iven.htm" target="_blank">Interactive Molecular model of cytochrome c oxidase</a>&#093; (Requires &#091;<a href="http://www.mdl.com/products/framework/chime/" target="_blank">MDL Chime</a>&#093;)</li></ul><p>

<p>

<p>

<p>


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