DEET
Encyclopedia : D : DE : DEE : DEET
| DEET | |
|---|---|
| |
| Systematic name | N,N-diethyl-3-methylbenzamide |
| Chemical formula | C12H17NO |
| Molecular mass | 191.27 g/mol |
| Density | ? g/cm3 |
| Melting point | ? °C |
| Boiling point | ? °C |
| CAS number | [134-62-3] |
| SMILES | CCN(CC)C(=O)C1=CC(=CC=C1)C |
| [Chemical infoboxDisclaimer and references] | |
DEET is an insect-repellent chemical. It is intended to be applied to the skin or to clothing, and is primarily used to protect against insect bites. In particular, DEET protects against tick bites (which transmit Lyme disease) and mosquito bites (which transmit dengue fever, West Nile fever and malaria).
DEET was developed by the United States Army, following its experience of jungle warfare during World War II. It entered military use in 1946 and civilian use in 1957.
DEET is the most common active ingredient in insect repellents. Studies into the health effects of using DEET in the approved way (as a topical application) have not shown any significant harm to human health; exposure to large amounts (by means such as accidental ingestion) has similar effects to comparable exposure to other pesticides. As DEET is a powerful pesticide, however, manufacturers of DEET based products advise they not be used under clothing, on damaged skin, and that the DEET based preparation be washed off after it is no longer needed or between applications.
Current mainstream medical opinion is that any dangers posed by DEET are greatly outweighed by those of the serious insect-borne diseases which DEET helps prevent. However, some newer repellents offer alternatives. Repellents containing picaridin or lemon eucalyptus oil were reported by Consumer Reports to be about as effective as repellents containing DEET, though medical studies have differed on the effectiveness of alternatives. A number of tests have shown DEET to be the most effective and longest-lasting insect repellent available.
However, recent studies by Duke University researchers have clearly shown that frequent and prolonged exposure to DEET by topical application, especially when in conjunction with exposure to other pesticides or chemicals, causes serious, diffuse brain cell death and behavioral changes in laboratory rats. The researchers warn the public to use DEET with caution, especially among populations like children who are more vulnerable to brain deficits that prolonged exposure to DEET causes. [link]
DEET is often sold and used in concentrations up to 100%. Although this offers the strongest short-term protection against insect bites, it is often not as effective in the long term as formulas containing less DEET (30%-60%). The reason for this is that pure DEET will not long adhere to human skin, and will evaporate, rub, or wash off in time. Formulas with lower concentrations often contain lotions or other agents which allow the formula to adhere to skin longer and provide longer-lasting protection. Any lessening of the strength of the protection as a result of the lower concentration may be countered by applying a greater quantity of the substance. Likewise, pure DEET may be reapplied as necessary to sustain the desired level of repellence.
DEET is believed to work by blocking insect receptors (notably those which detect carbon dioxide and lactic acid) which are used to locate hosts. DEET effectively "blinds" the insect's senses so the biting/feeding instinct is not triggered by humans or animals which produce these chemicals.
DEET can damage some plastics, rayon, spandex, other synthetic fabrics, leather, and painted or varnished surfaces; it does not damage natural fibers, such as cotton or wool, and has no effect on nylon.
References
- [Mosquitoes and Mosquito Repellents -- A Clinician's Guide -- Mark S. Fradin, MD -- Annals of Internal Medicine --] 1 June 1998, Volume 128. Issue 11 , Pages 931-940
- [Use Caution When Using DEET] Mohamed Abou-Donia, PhD; Professor of Pharmacology and Cancer Biology, Professor of Neurobiology at Duke University
External links
- [US Centers for Disease Control information on DEET]
- [US Environmental Protection Agency information on DEET]
- [Review of scientific literature on DEET] (from a RAND Corporation report on Gulf War illnesses)
- For a full list of external links to MSDSs, spectroscopic data, commercial chemicals suppliers etc. for this compound, see [Chemical sources].
See also
From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.