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Dehydration reaction

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In chemistry, a dehydration reaction is a chemical reaction that involves the loss of water from the reacting molecule. Dehydration reactions are a subset of elimination reactions.

In organic synthesis, there are many examples of dehydration reactions:

:2 R-OH → R-O-R + H2O
  • Conversion of alcohols to alkenes
  • :R-CH2-CHOH-R → R-CH=CH-R + H2O
  • Conversion of carboxylic acids to acid anhydrides
  • :2 RCO2H → (RCO)2O + H2O
  • Conversion of amides to nitriles
  • :RCONH2 → R-CN + H2O

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