Dodecamer
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Dodecameric is a term pertaining to protein quaternary structure, and describes a protein complex with 12 protein subunits (protein chains). Dodecameric complexes can have a number of subunit 'topologies', but typically only a few of the theoretically possible subunit arrangements are observed in protein structures.
A dodecamer is a protein complex with 12 protein subunits.
A common subunit arrangement involves a tetrahedral distribution of subunit trimers (or 3-4-point symmetry). Another observed arrangement of subunits puts two rings of six subunits side by side along the six fold axis (or 2-6-point symmetry).
Dodecameric proteins include
- glutamine synthetase (PDB code: 2gls)
- Dodecameric ferritin (PDB code: 1qgh)
References
- The Protein Data Bank (PDB)
- [The Protein Quaternary Structure Server] (PQS) (which is now a part of the [Macromolecular Structure Database] (MSD).
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