Ectopia lentis
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Ectopia lentis is a displacement or malposition of the eye's crystalline lens from its normal location. A partial dislocation of a lens is termed lens subluxation or subluxated lens; a complete dislocation of a lens is termed lens luxation or luxated lens.
Although observed in humans, it is most commonly seen in dogs. Ciliary zonules normally hold the lens in place. Luxation can occur from trauma, cataract formation, glaucoma, or abnormal development of the zonules. With anterior lens luxation, the lens pushes into the iris or actually enters the anterior chamber of the eye. This can cause glaucoma, uveitis, or damage to the cornea. With posterior lens luxation, the lens falls back into the vitreous humour and lays on the floor of the eye. This type causes less problems than anterior lens luxation. Surgery is used to treat dogs with significant symptoms.
Terrier breeds are predisposed to lens luxation, and it is probably inherited in the Sealyham Terrier, Jack Russell Terrier, Wirehaired Fox Terrier, and Tibetan Terrier.
Systemic associations
In humans, there are a number of systemic conditions that are associated with ectopia lentisEifrig CW, Eifrig DE. ["Ectopia Lentis"]. eMedicine.com. November 24, 2004.:More common:
- Marfan syndrome
- Homocystinuria
- Weill-Marchesani syndrome
- Sulfite oxidase deficiency
- Hyperlysinemia
- Ehlers-Danlos syndrome
- Crouzon disease
- Refsum syndrome
- Kniest syndrome
- Mandibulofacial dysostosis
- Sturge-Weber syndrome
- Conradi syndrome
- Pfaundler syndrome
- Pierre Robin syndrome
- Wildervanck syndrome
- Sprengel deformity
References
See also
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