Ethane methyl sulfonate

Encyclopedia : E : ET : ETH : Ethane methyl sulfonate

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Ethyl methyl sulfonate (CH3SO3CH2CH3) and ethyl ethane sulfonate (CH3CH2SO3CH2CH3) are ethylating of the purine ring and ends with the hydrolysis of the purine deoxyribose bond. It is assumed that, when DNA replication and repair take place, the repair enzyme is free to insert any of the four possible bases into the new strand as a complement to the gap created when these alkylating agents remove a purine. If thymine is placed in the newly formed strand, then the original base pair will be restored. Insertion of cytosine will result in a transition mutation; insertion of either adenine or guanine will result in a transversion mutation. Of course, the gap is still there to continue to generate new mutations each generation.

 

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