FTY720
Encyclopedia : F : FT : FTY : FTY720
FTY720 is a novel immunosuppressant drug that causes lymphopenia by redirecting lymphocytes from circulation to the lymph nodes. It is a chemical modification of the ISP-1 metabolite of the fungus Isaria sinclairii. It is a structural analogue of sphingosine and gets phosphorylated by sphingosine kinase 2 [1] [2]1 in the cell. It is currently in stage 3 clinical trials as a drug to be used to combat transplant rejection.
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