Fast atom bombardment
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Fast atom bombardment (FAB) is an ionization technique used in mass spectrometry in which an analyte and a non-volatile chemical protection environment (liquid matrix) mixture is bombarded by a ~8KeV particle beam of usually inert gas such as argon or xenon. Common matricies include glycerol and 3-nitrobenzyl alcohol (3-NBA). This technique is very closely related to (if not part of) secondary ion mass spectrometry. FAB is a relatively soft ionization technique and produces primarily protonated molecules denoted as [M+H]+ and deprotonated molecules such as [M-H]-. The nature of its ionization products places it close to electrospray and MALDI.
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References
- Barber, M.; Bordoli, R.S.; Sedgewick, R.D.; Tyler, A.N., Nature, 293, 1981, pp270-275.
- Barber, M.; Bordoli, R.S.; Elliott, G.J.; Sedgewick, R.D.; Tyler, A.N., Analytical Chemistry, 54, 1982, pp645A-657A.
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