Ghon's complex

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Ghon's complex is a part of the progression of the infectious respiratory disease commonly known as tuberculosis. Specifically, the Ghon's complex is a combination of the Ghon's focus (area of initial infection by airborne bacillus) and a lymphatic lesion. Approximately two to three weeks after the Ghon's focus has developed, the area undergoes caseous (cheeselike) necrosis. Free tubercle bacilli, or bacilli within macrophages drain out from the area towards the affected lungs' lymph nodes. It is in this location, at the lymph nodes, that the bacilli will form caseous granulomas. This, in combination with the initial area of infection, will make up the Ghon's complex.

References

Porth, Carol Mattson. Pathophysiology:Concepts of Altered Health States, 7th edition. Philadelphia: Lippincott Williams & Wilkins, 2005.

 

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