Glibenclamide
Encyclopedia : G : GL : GLI : Glibenclamide
Glibenclamide (INN), also known as glyburide (USAN), is an anti-diabetic drug in a class of medications known as sulfonylureas, used in the treatment of type II diabetes. The drug works by inhibiting ATP-sensitive potassium channels in pancreatic beta cells. This inhibition causes cell membrane depolarization, opening of voltage-dependent calcium channels, thus triggering an increase in intracellular calcium into the beta cell which stimulates insulin release. It is sold in doses of 1.25mg, 2.5mg and 5mg, under the trade names Diabeta®, Glynase® and Micronase® in the United States and Daonil®, Semi-Daonil® and Euglucon® in the United Kingdom.
It is also sold in combination with metformin under the trade name Glucovance®.
The drug is contraindicated in pregnant women. It is also a major cause of drug induced hypoglycaemia.
| Oral antidiabetic drugs (A10B) [http://encycl.opentopia.com/ edit] |
|---|
| ATC_code_A10#A10BA_Biguanides>A10BA - Biguanide - |
| ATC_code_A10#A10BB_Sulfonamides.2C_urea_derivatives>A10BB - Sulfonylureas - |
| ATC_code_A10#A10BF_Alpha_glucosidase_inhibitors>A10BF - Alpha-glucosidase inhibitor - |
| ATC_code_A10#A10BG_Thiazolidinediones>A10BG - Thiazolidinediones (TZD) - |
| ATC_code_A10#A10BX_Other_oral_blood_glucose_lowering_drugs>A10BX - Meglitinide - |
| no ATC - Dipeptidyl peptidase-4 inhibitors>Dipeptidyl peptidase-4 (DPP-4) inhibitors - |
From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.