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Glutathione peroxidase

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Glutathione Peroxidase 1
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Glutathione Peroxidase 1

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|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [GPX1] |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [2876] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [138320] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_000581] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [P07203] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [1.11.1.9] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 3[p21.3] |- |}
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|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [GPX3] |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [2878] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [138321] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_002084] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [P22352] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [1.11.1.9] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 5[q23] |- |}
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|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [GPX5] |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [2880] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [603435] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_001509] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [O75715] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [1.11.1.9] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 6[p21.32] |- |}
|- | align="center" colspan="2" |
|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [GPX6] |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [257202] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [607913] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_182701] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [P59796] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [1.11.1.9] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 6[p21] |- |} Glutathione peroxidase (PDB [1GP1], EC [1.11.1.9]) is a peroxidase found in the erythrocytes of mammals that helps prevent lipid peroxidation of the cell membrane. The function of glutathione peroxidase, therefore, is to reduce lipidhydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water. An example reaction that glutathione peroxidase catalyzes is:

2GSH + H2O2 → GSSG + 2H2O,
where GSH represents reduced monomeric glutathione, and GSSG represents oxidized glutathione. Glutathione reductase then reduces the oxidized glutathione to complete the cycle:

GSSG + NADPH + H+ → 2 GSH + NADP+.
Glutathione peroxidase is a selenium-containing tetrameric glycoprotein, that is, a molecule with four selenocysteineamino acid residues. As the integrity of the cellular and subcellular membranes depends heavily on glutathione peroxidase, the antioxidative protective system of glutathione peroxidase itself depends heavily on the presence of selenium.

The bovine erythrocyte enzyme has a molecular weight of 84 kDa.

See also

 


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