H2N2

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H2N2 is a subtype of the species Influenza A virus (sometimes called bird flu virus). H2N2 has mutated into various strains including the Asian Flu strain (now extinct in the wild), H3N2, and various strains found in birds.

It is suspected of causing a human pandemic in 1889. [link] [link]

Contents

1 Asian flu
2 Test kits
3 Sources
4 Further reading

Asian flu

The "Asian Flu" was a pandemic outbreak of avian influenza that originated in China in 1957 and spread worldwide that same year, lasting until 1958. Estimates of worldwide casualty numbers vary widely, ranging from one million to four million people.

Asian Flu was of the H2N2 strain (a notation that refers to the configuration of the hemagglutinin and neuraminidase proteins in the virus) of type A influenza, and a flu vaccine was developed in 1957 to contain its outbreak.

The Asian Flu strain later evolved via antigenic shift into H3N2 which caused a milder pandemic from 1968 to 1969.

Both the H2N2 and H3N2 pandemic strains contained Avian flu virus RNA segments. "While the pandemic human influenza viruses of 1957 (H2N2) and 1968 (H3N2) clearly arose through reassortment between human and avian viruses, the influenza virus causing the 'Spanish flu' in 1918 appears to be entirely derived from an avian source (Belshe 2005)." [Chapter Two : Avian Influenza by Timm C. Harder and Ortrud Werner] from excellent free on-line Book called Influenza Report 2006 which is a medical textbook that provides a comprehensive overview of epidemic and pandemic influenza.''

Test kits

From October 2004 to February 2005, some 3,700 test kits of the 1957 H2N2 virus were accidentally spread around the world from the College of American Pathologists (CAP). CAP assists laboratories in accuracy by providing unidentified samples of viruses; private contractor Meridian Bioscience in Cincinnati, U.S., chose the 1957 strand instead of one of the less deadly avian influenza virus subtypes. "CAP spokesman Dr. Jared Schwartz said Meridian knew what the virus was but believed it was safe. In selecting it, the company had determined that the virus was classified as a biosafety level 2 (BSL-2) agent, which meant it could legally be used in the kits. [...] Before the problem came to light, the CDC had made a recommendation that the H2N2 virus be reclassified as a BSL-3 agent, Gerberding said. She promised to speed up the reclassification. The CDC determines the classifications in collaboration with the National Institutes of Health. In BSL-3 labs, agents are handled with equipment designed to prevent any airborne contamination and resulting respiratory exposure." [link] The 1957 H2N2 virus is considered deadly and the U.S. government called for the vials containing the strain to be destroyed.

"CDC officials reported on April 21 that 99% of the samples had already been destroyed. News reports on April 25 said the last samples outside the United States had been destroyed at the American University of Beirut in Lebanon, after they were found at the Beirut airport. Earlier reports said H2N2 samples were sent to 3,747 labs under CAP auspices and to about another 2,700 labs certified by other organizations. All but about 75 labs that received the CAP samples were in the United States." [link]

"In the United States, there is no government regulation over the 1957 flu strain. In fact, federal officials at the CDC do not even know how many U.S. laboratories keep this deadly strain in their viral libraries." [link]

H2N2

Asian flu

Test kits

Sources

Further reading