H4 receptor
Encyclopedia : H : H4 : H4R : H4 receptor
The H4 histamine receptor was first published by Nguyen et al in March of 2001, who also published the gene encoded it in a search of the GenBank databases. Like the other three histamine receptors, it is also a G protein-coupled receptor.
Contents
Where Found
H4 is highly expressed in bone marrow and white blood cells and regulates zymosan-induced neutrophil release from bone marrow and subsequent infiltration in the pleurisy model along with L-selectin.[#endnote_H4bonemarrow] It is also expressed in the colon, liver, lung, small intestine, spleen, testes, thymus, tonsils, and trachea.[#endnote_otherorgans]
Functions
They have been shown to mediate mast cell chemotaxis.[#endnote_chemotaxis] ...and moreHigh Affinity Substances
The following substances have been found to bind with high affinity to this receptor:Moderate Affinity Substances
The following substances have been found to bind with moderate affinity to this receptor:Weak Affinity Substances
The following substances have been found to bind with weak affinity to this receptor:- imetit
- pheniramine
- dimaprit
References
- Tuan Nguyen, David A. Shapiro, Susan R. George, Vincent Setola, Dennis K. Lee, Regina Cheng, Laura Rauser, Samuel P. Lee, Kevin R. Lynch, Bryan L. Roth, and Brian F. O'Dowd [Discovery of a Novel Member of the Histamine Receptor Family] The Journal of Molecular Pharmacology Vol. 59, Issue 3, 427-433, March 2001
End Notes
- ↑ Keisuke Takeshita, and Kevin B. Bacon, Florian Gantner [Critical Role of L-Selectin and Histamine H4 Receptor in Zymosan-Induced Neutrophil Recruitment from the Bone Marrow: Comparison with Carrageenan] The Journal of Pharmacology and Experimental Therapeutics
- ↑ [Bioreagents.com: Histamine H4 Receptor]
- ↑ Claudia L. Hofstra, Pragnya J. Desai, Robin L. Thurmond, and Wai-Ping Fung-Leung [Histamine H4 Receptor Mediates Chemotaxis and Calcium Mobilization of Mast Cells] Journal of Pharmacology And Experimental Therapeutics First published on March 6, 2003
External links
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