Homeostatic model assessment

Encyclopedia : H : HO : HOM : Homeostatic model assessment

The homeostatic model assessment (HOMA) is a method used to quantify insulin resistance. It was first described by Matthews et al in 1985.

Derivation

Using a fasting blood sample, it is derived by use of the insulin-glucose product, divided by a constant:

Glucose (mg/dL)) x Insulin (µU/mL) / 405

In this equation, one should use the constant 22.5 instead of 405 if the glucose is reported in mmol/L. This model correlates well with estimates using the euglycemic clamp method (r = 0.88).

Source

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-9. PMID 3899825.

From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.