Juan, Prince of Asturias
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Infante don Juan de Trastamare de Aragon y de Trastamare de Castilla, (June 28 1478 in Seville–October 4 1497), Prince of Asturias and heir of Spain, was the only son of Isabella of Castile and Ferdinand II of Aragon who survived to adulthood. At the age of 18 he married Margaret of Austria (1480-1530) in the Cathedral of Burgos in April, 1497. Six months later, on the way to the wedding of his older sister in Portugal, he died in Salamanca, possibly from tuberculosis. There were no offspring.
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