KvLQT1

Encyclopedia : K : KV : KVL : KvLQT1

KvLQT1 is a potassium channel protein coded for by the gene KCNQ1. Mutation in the gene can lead to a defective protein and several forms of inherited arrhythmias as Long QT syndrome, Short QT syndrome, and Familial Atrial Fibriillation. Currents arrising from KvLQT1 in over-expression systems are never recapitulated in native tissues - KvLQT1 is always found in native tissues with a modulatory subunit. Though physiologically irrelevant, homotetrameric KvLQT1 channels also display a unique form of N-type inactivation that reaches quilibrium quickly, allowing KvLQT1 currents to plateau. This is different from the inactivation seen in A-type currents, in which most of the current never returns.

From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.