Langerhans cell
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Langerhans' cells are immature dendritic cells containing large granules called Birbeck granules. On infection of an area of skin, the local Langerhans' cells will take up and process microbial antigens before travelling to the T-cell areas in the cortex of the draining lymph node and maturing to become fully-functional antigen-presenting cells.
Generally, dendritic cells in tissue (such as Langerhans' cells) are active in the capture, uptake and processing of antigens. Once dendritic cells arrive in secondary lymphoid tissue however, they lose these properties while gaining the capacity to interact with naive T-cells.
In the rare disease Langerhans' cell histiocytosis (LCH), these cells are being excessively produced and cause damage to bones.
Langerhans' cells are derived from the cellular differentiation of monocytes with the marker "Gr-1" (also known as "Ly-6c/G"). The differentiation requires stimulation by colony stimulating factor-1 (PMID 16444257).
See also
External links
| Blood - Blood plasma - [http://encycl.opentopia.com/ edit] |
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| Pluripotential hemopoietic stem cells | Red blood cells (Reticulocyte, Normoblast) | White blood cells |
| Lymphocytes (Lymphoblast) |
| T cells (Cytotoxic, Helper, Regulatory T cells, Natural Killer T cells) | B cells (Plasma cells & Memory B cells) | Natural killer cells |
| Myelocytes (Myeloblast) |
| Granulocytes (Neutrophil granulocyte>Neutrophil, Eosinophil, Basophil) | Mast cell precursors | Monocytes (Histiocyte, Macrophages, Dendritic cells, Langerhans cells, Microglia, Kupffer cells, Osteoclasts) | Megakaryoblast | Megakaryocyte | Platelets |
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