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Luigi Luca Cavalli-Sforza

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Cover image of The History and Geography of Human Genes, (1994), mapping the 3 strongest principal components of variation of 82 selected genes (p. 134) (mostly blood type and HLA genes which are subject to selection by disease (p. 126), not neutral markers) between his sampled populations onto green, blue and red respectively; the 4th and lower PCs are ignored. The New World is cut off here.
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Cover image of The History and Geography of Human Genes, (1994), mapping the 3 strongest principal components of variation of 82 selected genes (p. 134) (mostly blood type and HLA genes which are subject to selection by disease (p. 126), not neutral markers) between his sampled populations onto green, blue and red respectively; the 4th and lower PCs are ignored. The New World is cut off here.

Luigi Luca Cavalli-Sforza (born January 25, 1922) is an Italian population geneticist born in Genoa, who has been a professor at Stanford University since 1970 (now emeritus). One of the most important geneticists of the 20th century, he has summed up his work for laymen under five topics covered in Genes, Peoples, and Languages (2000). Physiologist and evolutionary biologist Jared Diamond praised the work for "demolishing scientists' attempts to classify human populations into races in the same way that they classify birds and other species into races." According to an article published in The Economist, the work of Cavalli-Sforza "challenges the assumption that there are significant genetic differences between human races, and indeed, the idea that 'race' has any useful biological meaning at all." [link] (The Human Genome Survey, 1 July 2000, pg. 11) On the other hand, reporter and essayist Steve Sailer has argued that Cavalli-Sforza's life work is in fact, "distinguishing the races of mankind and compiling their genealogies", but that he takes pains to avoid using those terms in order to avoid their political connotations. [link]

Cavalli-Sforza's The History and Geography of Human Genes (1994 with Paolo Menozzi and Alberto Piazza) is considered a standard reference on human genetic variation. Cavalli-Sforza also wrote The Great Human Diasporas: The History of Diversity and Evolution (with his son Francesco).

Once the genetic structure of inheritance had been made plain, Cavalli-Sforza was one of the first scientists to ask whether the genes of modern populations might contain an inherited historical record of the human species. The study of demographics was already well-established, based on linguistic, cultural, and archaeological clues, but it had become overlaid with nationalist and racist ideologies. Cavalli-Sforza initiated a new field of research by combining the concrete findings of demography with a newly-available analysis of blood groups in an actual human population.

Cavalli-Sforza has studied the connections between migration patterns and blood groups.

While Cavalli-Sforza is most often credited with his work in genetics, he also, in collaboration with Marcus Feldman, initiated the sub-discipline of cultural anthropology known alternatively as coevolution, gene-culture coevolution, cultural transmission theory or dual inheritance theory. The seminal publication [[Cultural Transmission and Evolution: A Quantitative Approach]] (1981) made use of models from population genetics to investigate the transmission of culturally transmitted units. This line of inquiry initiated research into the correlation of patterns of genetic and cultural dispersion.

An autosomal DNA plot of genetic distances derived from 120 allele frequencies in Cavalli-Sforza's "The History and Geography of Human Genes"
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An autosomal DNA plot of genetic distances derived from 120 allele frequencies in Cavalli-Sforza's "The History and Geography of Human Genes"

Cavalli-Sforza received his M.D. from the University of Pavia in 1944. His post-war studies at Cambridge in the area of bacterial genetics were followed by years of teaching in northern Italy, in Milan, Parma, and Pavia, and a move in 1970 to Stanford, where he found the intellectual culture more open-ended and cooperative, and where he has remained.

Criticism

In a paper published in 1997, Shomarka Keita and Rick A. Kittles have criticized the primary methodology used by Cavalli-Sforza and other like-minded geneticists, pointing out the "inappropriateness of using a priori predefined racial categories and then sorting genetic diversity as much as possible into these categories." [link] (Evolutionary Anthropology, pg. 39) In some cases, groups generated by cluster analysis of genetic data reproduce traditional racial categories, but in some further analysis Cavalli-Sforza uses groupings like Extra-European Caucasoid that are apparently a priori and not generated by the data itself.

His proposed ambitious Human Genome Diversity Project to gather further genetic data from populations around the world was accused of "cultural insensitivity, neocolonialism, and biopiracy." [link]

Linguist Bill Poser in Language Log has criticized some of Cavalli-Sforza's comments about linguistics, [link] in particular the suggestion, echoing controversial linguists Merritt Ruhlen and Joseph Greenberg, that some mainstream linguists are unnecessarily conservative about hypothesized long-range relationships between language families, and an overstatement that Greenberg's critics "have ruled out the possibility of hierarchical classification", which Cavalli-Sforza did not defend when challenged by Poser, but deferred to Ruhlen. Cavalli-Sforza's interest in hypothesized large-scale language families is as a basis for comparison with similarly large-scale postulated genetic classifications of human populations.

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