Melanin concentrating hormone

Encyclopedia : M : ME : MEL : Melanin concentrating hormone

Melanin-concentrating hormone (MCH) is a cyclic orexinogenic hypothalamic peptide involved in the regulation of feeding behavior and energy balance. When administered artificially, it increases food intake. It also seems to activate the stress axis. Two receptors have recently been characterized: MCH-R1 and MCH-R2. Antagonists might be useful in the treatment of obesity. Research is ongoing for antagonists affecting MCH receptors R1 and R2.

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