Metoprolol

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"Minax" redirects here. For , see Minax (Ultima).

Metoprolol is a selective beta₁ receptor blocker used in treatment of several diseases of the cardiovascular system. It is marketed under the brand name Lopressor® by Novartis, and Toprol® (in the USA), Seleken® or Selokeen® (elsewhere) by "Betaloc®" AstraZeneca and as Corvitol® by Berlin-Chemie AG. Generic brands marketed in the Australasian region include "Minax®" Alphapharm, "Metrol®" Arrow and "Metohexal®" Hexal.

It should be noted that Lopresor® refers to metoprolol tartrate, while Toprol® refers to metoprolol succinate, the sustained-release formulation.

Properties:

Cardioselective
Lipophilic
Without intrinsic sympathomimetic activity (ISA)
Without membrane stabilizing activity
Short half-life must be taken at least twice daily or SR preparations

Indications:

Essential hypertension
Arrhythmias
Coronary heart disease (prevention of angina attacks)
Secondary prevention after a myocardial infarction
Low dosed treatment of some forms of heart failure (see MERIT-HF study¹)
Migraine prophylaxis
Adjunct in treatment of hyperthyroidism

In the United States and most other countries, this medication is available only by prescription.

References

"Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF)" Lancet. 1999 Jun 12;353(9169):2001-7. PMID 10376614.

Beta blockers (C07) [http://encycl.opentopia.com/ edit]

Non-selective β antagonists (C07AA) [ edit]

β₁ antagonists (cardioselective) (C07AB) [ edit]

Mixed α₁/β antagonists (C07AG) [ edit]

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