Mokola virus

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Mokola virus is one of four members of the lyssavirus genome found in Africa, the others being Duvenhage virus, Lagos bat virus and classical rabies virus. Mokola virus was first isolated from shrews (Crocidura species) from Mokola forest, Nigeria in 1968. It has caused two human deaths in Nigeria, in 1968 and 1971. It causes lethal encephalitis, and does not manifest the features of classic rabies.

Mokola virus has also been found in numerous other mammalian species in sub-Saharan Africa, including domestic cats in Zimbabwe and South Africa. Some of these cats had received rabies vaccine but remained susceptible to Mokola virus infection.

The reservoir for Mokola virus is unknown. Unlike other lyssaviruses, Mokola virus is able to infect and replicate in mosquito cells and so may be harboured by insects.

 

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