Moxonidine

Encyclopedia : M : MO : MOX : Moxonidine

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Moxonidine is a , a centrally acting antihypertensive drug licensed for mild to moderate essential hypertension. It may have a role when thiazides, beta-blockers, ACE inhibitors and calcium-channel blockers are not appropriate or have failed to control blood pressure.

Cautions

renal impairment (Appendix 3); avoid abrupt withdrawal (if concomitant treatment with beta-blocker has to be stopped, discontinue beta-blocker first, then moxonidine after few days); interactions: see Appendix 1 (moxonidine)

Contra-indications

It is contraindicated if there has been a past history of angioedema; heart conduction disorders (e.g. sick sinus syndrome, second- or third-degree heart block); bradycardia; severe heart failure or coronary artery disease, severe liver or renal impairment. Also: Raynaud's syndrome, intermittent claudication, epilepsy, depression, Parkinson's disease, glaucoma; pregnancy or breast-feeding

Side-effects

dry mouth; headache, fatigue, dizziness, nausea, sleep disturbance (rarely sedation), asthenia, vasodilatation; rarely skin reactions

Dose

200 micrograms once daily in the morning, increased if necessary after 3 weeks to 400 micrograms daily in 1–2 divided doses; max. 600 micrograms daily in 2 divided doses (max. single dose 400 micrograms)

 

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