Nodal (protein)
Encyclopedia : N : NO : NOD : Nodal (protein)
| Nodal | |
|---|---|
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| |
| Gene code: | HUGO code:[NODAL] |
| Structure: | |
| Recent publications: | |
| protein type: | cytokine |
| Functions: | cell differentiation |
| Domains: | TGFβ domain |
| Diseases: | Situs Ambiguus OMIM [601265] |
| Taxa expressing: | Homo sapiens; homologs: many metazoan phyla |
| Cell types: | many |
| Subcellular localization: | Extracellular |
| covalent modifications | |
| Other names: | |
| Molecular interactions | |
| related articles: | |
Nodal is a polypeptide member of the TGF beta superfamily of polypeptides. Like many other members of this superfamily, it is invovled in cell differentiation. Nodal plays an essential role in mesoderm formation and axis specification. Nodal null mice die shortly after gastrulation.
References
| TGF beta signaling pathway[http://encycl.opentopia.com/ edit] | |
|---|---|
| TGF beta superfamily of ligands: | |
| Activin A | Activin B | Anti-müllerian hormone | BMP2 | BMP3 | BMP4 | BMP5 | BMP6 | BMP7 | BMP8a | BMP8b | BMP15 | GDF1 | GDF2 | GDF3 | GDF5 | GDF6 | GDF7 | GDF9 | GDF10 | GDF11 | GDF15| Inhibin A | Inhibin B | Myostatin | Nodal | TGFβ1 | TGFβ2 | TGFβ3 | |
| Type II receptors: ACVR2A | ACVR2B | AMHR2 | BMPR2 | TGFBR2 | TGFBR3 | |
| Type I receptors: ACVR1A | ACVR1B | ACVR1C | ACVRL1 | BMPR1A | BMPR1B | TGFBR1 | |
| Signal transducers: SMAD1 | SMAD2 | SMAD3 | SMAD4 | SMAD5 | SMAD6 | SMAD7 | SMAD9 | |
| Ligand Inhibitors: Cerberus | Chordin | DAN | Decorin | Follistatin | Gremlin | Lefty | LTBP1 | Noggin | THBS1 | |
| Coreceptors: BAMBI | Cripto Other: SARA |
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