North American smallpox epidemic

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Between 1775 and 1782, a smallpox epidemic raged across much of North America, killing more than 130,000 people. Among the places it showed itself:

The town of Boston during the British occupation and the American siege of 1775.
The American invasion of Quebec, 1775.
Smallpox ravaged the populations of escaped slaves who fled to the British lines in the South during the American Revolutionary War.
New Orleans, 1778–1779
Tens of thousands of people died throughout Mexico beginning in 1779.
It swept through the Pueblos of New Mexico beginning in 1780.
It probably travelled among the people of the Great Plains.
It showed up in the interior trading posts of the Hudson's Bay Company in 1782

Further reading