Ogilvie syndrome

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Ogilvie syndrome is the acute pseudoobstruction and dilation of the colon in the absence of any mechanical obstruction in severely ill patients.[Neostigmine for the Treatment of Acute Colonic Pseudo-Obstruction], by Ponec R. J., Saunders M. D., Kimmey M. B., New England Journal of Medicine, 1999; 341:137-141, Jul 15, 1999.

Colonic pseudo-obstruction is characterized by massive dilatation of the cecum (diameter > 10 cm) and right colon on abdominal X-ray.[Recent Advances in Critical Care Gastroenterology] DANIEL S. PRATT and SCOTT K. EPSTEIN, [Am. J. Respir. Crit. Care Med.], Volume 161, Number 5, May 2000, 1417-1420

Contents

1 Aetiology
2 Pathophysiology
3 Treatment
4 See also
5 Notes
6 References

Aetiology

Recent surgery (most common following coronary artery bypass surgery),[Ogilvie Syndrome as a Postoperative Complication] Patty L. Tenofsky, MD; R. Larry Beamer, MD; R. Stephen Smith, MD [Arch Surg.] 2000;135:682-687. neurologic disorders, serious infections, cardiorespiratory insufficiency, metabolic disturbances, and drugs that disturb colonic motility (e.g., anticholinergics or narcotics) contribute to the development of this condition.

Pathophysiology

The exact mechanism behind the acute colonic pseudo-obstruction is not fully elucidated. The probable explanation is imbalance in the regulation of colonic motor activity by the autonomic nervous system.

Treatment

It usually resolves with conservative therapy but may require colonoscopic decompression which is successful in 70% of the cases. A study published in the New England Journal of Medicine showed that neostigmine is a potent pharmacological way of decompressing the colon. According to the American Society for Gastrointestinal Endoscopy (ASGE), it should be considered prior to colonoscopic decompression. The use of neostigmine is not without risk since it can induce bradyarrhythmia and bronchospasms. Therefore atropine should within immediate reach when this therapy is used.

Notes

References

[Intensive Care Medicine by Irwin and Rippe]
[Neostigmine for the Treatment of Acute Colonic Pseudo-Obstruction], by Ponec R. J., Saunders M. D., Kimmey M. B., New England Journal of Medicine, 1999; 341:137-141, Jul 15, 1999.