Progestin
Encyclopedia : P : PR : PRO : Progestin
A progestin is a synthetic progestagen. These particular synthetic hormones are most often used in the production of contraceptives.
Progestins are classified according to their structure in C19 and C21 progestagens. The C19 ones are derived from testosterone, the C21 ones from progesterone. C21 progestagens include cyproterone acetate, dydrogesterone, medroxyprogesterone acetate, chlormadinone acetate, megestrol and promegestone. Of these, dydrogesterone is structurally most similar to progesterone. C19 progestagens include norethisterone, (levo)norgestrel, lynestrenol, desogestrel, norgestimate, gestodene and tibolone.
Different progestins have different combinations of androgen (testosterone-like) and progesterone activity. If the activity of 1 mg of norethindrone is taken as the baseline, 1 mg of the other progestins have activities as follows:
| Progestin | Progestational activity | Androgen activity |
| norethindrone | 1 | 1 |
| norethindrone acetate | 1.2 | 1.6 |
| desogestrel | 9 | 3.4 |
| drospirenone | 1.5 | 0 |
| ethynodiol diacetate | 1.4 | 0.6 |
| norelgestromin | 1.3 | 1.9 |
| norgestimate | 1.3 | 1.9 |
| levonorgestrel | 5.3 | 8.3 |
| dl-norgestrel | 2.6 | 4.2 |
Norethindrone was synthesized for the first time in 1951 by the Mexican chemist Luis E. Miramontes. This substance became the basis for the contraceptive pill.
From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.