|-
| align="center" colspan="2" |
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| colspan="2" bgcolor="#dddddd" | Identifiers
|-
| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [F2RL3]
|-
| bgcolor="#e7dcc3" | Entrez
| bgcolor="#eeeeee" | [9002]
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | OMIM
| bgcolor="#eeeeee" | [602779]
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| bgcolor="#e7dcc3" | RefSeq
| bgcolor="#eeeeee" | [NM_003950]
|-
| bgcolor="#e7dcc3" | UniProt
| bgcolor="#eeeeee" | [Q96RI0]
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | PDB
| bgcolor="#eeeeee" | []
|-
| colspan="2" bgcolor="#dddddd" | Other data
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | EC number
| bgcolor="#eeeeee" | []
|-
| bgcolor="#e7dcc3" | Locus
| bgcolor="#eeeeee" | Chr. 19[p12]
|-
|}
A protease-activated receptor is a cell receptor that is activated by cleavage of part of its extracellular domain. It is located not only on platelets, but also on endothelial cells, myocytes and neurons.
There are 4 known protease-activated receptors or PAR's, numbered from one to four. These receptors are members of the seven transmembrane G-protein-coupled receptor superfamily, and are expressed throughout the body.
PAR's are activated by the action of serine based proteases such as thrombin (acts on PAR's 1, 3 and 4) and trypsin (PAR 2). These enzymes act upon the N-terminus of the receptor, and cause the formation of a tethered ligand. In this state, part of the receptor itself acts as the agonist, causing a physiological response.
Most of the PAR family act through the actions of G-proteins i (cAMP inhibitory), 12/13(Raf/Ras activation) and q (calcium signalling) to cause cellular actions.
Recent research has implicated these novel receptors in the inflammatory response (including arthritis), muscle growth, and bone cell differentiation and proliferation.
