Protein family

Encyclopedia : P : PR : PRO : Protein family

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A protein family is a group of evolutionarily related proteins.

As the total number of sequenced proteins increases and interest expands in proteome analysis, there is an ongoing effort to organize proteins into families and to describe their component domains and motifs. Reliable identification of protein families is key to phylogenetic analysis, functional annotation and the exploration of diversity of protein function in a given phylogenetic branch.

The algorithmic means for establishing protein families on large scale are based on a notion of similarity. Most of the time the only similarity we have access to is sequence similarity.

See also

• homology
• sequence clustering
• genome annotation
• SCOP
• CATH
• InterPRO

External links

• [Pfam: Protein families database of alignments and HMMs]
• [PIRSF: SuperFamily Classification System]
• [http://caps.ncbs.res.in/campass/pass2.html PASS2: PASS2 - Protein Alignment as Structural Superfamilies v2 - PASS2@NCBS

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