Substance P

Encyclopedia : S : SU : SUB : Substance P

|- | align="center" colspan="2" |

|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [TAC1] TAC2, NKNA |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [6863] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [162320] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_003182] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [P20366] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 7[q21-q22] |- |} |- | align="center" colspan="2" |

|- | colspan="2" bgcolor="#dddddd" | Identifiers |- | bgcolor="#e7dcc3" | Symbol(s) | bgcolor="#eeeeee" | [TACR1] TAC1R |- | bgcolor="#e7dcc3" | Entrez | bgcolor="#eeeeee" | [6869] |- class="hiddenStructure" | bgcolor="#e7dcc3" | OMIM | bgcolor="#eeeeee" | [162323] |- | bgcolor="#e7dcc3" | RefSeq | bgcolor="#eeeeee" | [NM_001058] |- | bgcolor="#e7dcc3" | UniProt | bgcolor="#eeeeee" | [P25103] |- class="hiddenStructure" | bgcolor="#e7dcc3" | PDB | bgcolor="#eeeeee" | [] |- | colspan="2" bgcolor="#dddddd" | Other data |- class="hiddenStructure" | bgcolor="#e7dcc3" | EC number | bgcolor="#eeeeee" | [] |- | bgcolor="#e7dcc3" | Locus | bgcolor="#eeeeee" | Chr. 2[p13.1-p12] |- |} In neuroscience, Substance P is a neuropeptide: a short-chain polypeptide that functions as a neurotransmitter and as a neuromodulator. It belongs to the tachykininneuropeptide family.

Substance P is an 11-amino acid polypeptide with the sequence: Arg Pro Lys Pro Gln Gln Phe Phe Gly Leu Met NH2. In central nervous system substance P has been associated in the regulation of mood disorders, anxiety, stress, reinforcement, neurogenesis, respiratory rhythm, neurotoxicity, nausea / emesis and pain.

It also has effects as a potent vasodilator. This is caused by the release of nitric oxide from the endothelium. Its release can cause hypotension.

The endogenous receptor for Substance P is neurokinin 1 receptor (NK1-receptor, NK1R). It belongs to the tachykinin receptor sub-family of GPCRs.

Substance P antagonist (SPA) aprepitant is available in the market in the treatment of chemotherapy-induced nausea / emesis.

Substance P is involved in the transmission of pain impulses from peripheral receptors to the central nervous system. It has been theorised that it plays a part in fibromyalgia. Capsaicin has been shown to reduce the levels of Substance P probably by reducing the number of C-fibre nerves or causing these nerves to be more tolerant.

Naked Mole Rats lack Substance P and do not feel pain when painful stimuli are administered.

External links

• http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=36511 Substance P in PubChem

 

---

From Wikipedia, the Free Encyclopedia. Original article here. Support Wikipedia by contributing or donating.
All text is available under the terms of the GNU Free Documentation License See Wikipedia Copyrights for details.

Search Titles

0

1

2

3

4

5

6

7

8

9

A

B

C

D

E

F

G

H

I

J

K

L

M

N

O

P

Q

R

S

T

U

V

W

X

Y

Z

?