Thiamine

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Thiamine

Systematic name	Thiamine
Chemical formula	C₁₂H₁₇N₄OS
Molecular mass	266.4 g/mol
Density	x.xxx g/cm³
Melting point	248-250 °C (hydrochloride salt)
Boiling point	xx.x °C
CAS number	[59-43-8]
SMILES	xxxx
[Chemical infoboxDisclaimer and references]

For the similarly-spelled nucleic acid, see Thymine

Thiamine or thiamin, also known as vitamin B₁, is a colorless compound with chemical formula C₁₂H₁₇N₄O S. It is soluble in water and insoluble in alcohol. Thiamine decomposes if heated. Thiamine was first discovered by Umetaro Suzuki in Japan when researching how rice bran cured patients of Beriberi. He named it aberic acid.

Contents

1 Biological roles
2 Nutrition

2.1 Deficiency
2.2 Diagnostic Testing for B1 Deficiency
2.3 Overdose
2.4 Genetic diseases
2.5 Good sources

3 References
4 External links

Biological roles

Thiamine pyrophosphate (TPP)

Thiamine pyrophosphate (TPP) is a coenzyme for pyruvate dehydrogenase, α-ketoglutarate dehydrogenase and transketolase. The first two of these enzymes function in the metabolism of carbohydrates, while transketolase functions in the pentose phosphate pathway to synthesize NADPH and the pentose sugars deoxyribose and ribose. TPP is synthesized by the enzyme thiamine pyrophosphokinase, which requires free thiamine, magnesium, and adenosine triphosphate.

Nutrition

Also known as vitamin B1, thiamine plays an important role in helping the body convert carbohydrates and fat into energy. It is essential for normal growth and development and helps to maintain proper functioning of the heart and the nervous and digestive systems. Thiamine is water-soluble and cannot be stored in the body; however, once absorbed, the vitamin is concentrated in muscle tissue.

Deficiency

Systemic thiamine deficiency can lead to myriad problems including neurodegeneration, wasting, and death. A lack of thiamine can be caused by malnutrition, a diet high in thiaminase-rich foods (raw freshwater fish, raw shellfish, ferns) and/or foods high in anti-thiamine factors (tea, coffee, betel nuts) [link].

Well-known syndromes caused by thiamine deficiency include Wernicke-Korsakoff syndrome and beriberi, diseases also common in chronic abusers of alcohol.

Diagnostic Testing for B1 Deficiency

A positive diagnosis test for Thiamine deficiency can be assertained by measuring erythrocyte levels of transketolase in serum.

Overdose

The only known cases of thiamine overdose occurred with thiamine injections. Thiamine injection may result in anaphylactic reactions.

Genetic diseases

Genetic diseases of thiamine transport are rare but serious. [Thiamine Responsive Megaloblastic Anemia with diabetes mellitus and sensorineural deafness (TRMA)] is an autosomal recessive disorder caused by mutations in the gene [SLC19A2], a high affinity thiamine transporter. TRMA patients do not show signs of systemic thiamine deficiency, suggesting redundancy in the thiamine transport system. This has led to the discovery of a second high affinity thiamine transporter, [SLC19A3].

Good sources

Thiamine is found naturally in the following foods, each of which contains at least 0.1mg of the vitamin per 28-100g (1-3.5oz): - Green peas - Spinach - Liver - Beef - Pork - Navy beans - Nuts - Pinto beans - Soybeans

References

[Linus Pauling Institute Micronutrient Information Center] - Thiamin

External links

For a full list of external links to MSDSs, spectroscopic data, commercial chemicals suppliers etc. for this compound, see [Chemical sources].

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