Tim's Ligand
Encyclopedia : T : TI : TIM : Tim's Ligand
Tim's ligand, or TBTA (tris-(benzyl-triazolylmethyl-amine)) is a ligand which when attached to Copper (I) allows for quantitative, regioselective Huisgen 1,3-dipolar cycloadditions between alkynes and azides, in a variety of aqueous and organic solvents. It is believed that the ligand promotes catalysis through the stabilization of the copper(I)-oxidation state while simultaneously accelerating catalytic rates. Tim's ligand is named after Tim Chan, who developed this molecule for use as a biological labelling tool while working as a graduate student for K. Barry Sharpless.
References
- Org. Lett.; 2004; 6(17) pp 2853 - 2855;
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