Tissue factor pathway inhibitor
Encyclopedia : T : TI : TIS : Tissue factor pathway inhibitor
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| colspan="2" bgcolor="#dddddd" | Identifiers
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| bgcolor="#e7dcc3" | Symbol(s)
| bgcolor="#eeeeee" | [TFPI ] LACI
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| bgcolor="#e7dcc3" | Entrez
| bgcolor="#eeeeee" | [7035 ]
|- class="hiddenStructure"
| bgcolor="#e7dcc3" | OMIM
| bgcolor="#eeeeee" | [152310 ]
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| bgcolor="#e7dcc3" | RefSeq
| bgcolor="#eeeeee" | [NM_001032281 ]
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| bgcolor="#e7dcc3" | UniProt
| bgcolor="#eeeeee" | [P10646 ]
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| bgcolor="#e7dcc3" | PDB
| bgcolor="#eeeeee" | [Other data
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| bgcolor="#e7dcc3" | EC number
| bgcolor="#eeeeee" | [Locus
| bgcolor="#eeeeee" | Chr. 2 [q31-q32.1 ]
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Tissue factor pathway inhibitor (or TFPI ) is a single-chain polypeptide which can reversibly inhibit Factor X a (Xa). While Xa is inhibited, the Xa-TFPI complex can subsequently also inhibit the FVIIa -TF complex.
TFPI contributes significantly to the inhibition of Xa in vivo, despite being present at concentrations of only 2.5nM.
Genetics
The gene for TFPI is located on chromosome 2q31-q32.1, and has nine exons which span 70kb. The gene has not been completely sequenced yet. A similar gene, termed TFPI2 , has been identified on chromosome 7q22; in addition to TFPI activity, its product also has retinal pigment epithelial cell growth-promoting properties.
Protein structure
TFPI has a relative molecular mass of 34000 to 40000 depending on the degree of proteolysis of the C-terminal region.
See also
External link
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