Trail
Encyclopedia : T : TR : TRA : Trail
TNF-related apoptosis-inducing ligand (TRAIL), in the field of cell biology, is a ligand molecule which induces the process of cell death called apoptosis. It is a type II transmembrane protein with homology to other members of the tumor necrosis factor family.
In humans, the gene that encodes for TRAIL is located at chromosome 3q26.
TRAIL binds to the death receptors, DR4 and DR5. The process of apoptosis is caspase-8-dependent.
References
- PMID 8777713 - Wiley SR et al. Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity. 1995 Dec;3(6):673-82.
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