William Murphy
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William Murphy may refer to:
- William Parry Murphy (1892–1987), American doctor and Nobel Prize winner
- William Murphy (Irish politician) (1892–1967), Irish Fine Gael TD 1951–1969
- William Beverly Murphy (1907–1994), American food businessman
- William Murphy, American actor
- William Murphy (bishop), Roman Catholic bishop in Rockville Centre, New York
- William F. Murphy, Jr., Blackbelt in Brazilian Jiu-Jitsu, Acute Lymphocytic Leukemia Survivor
- William Murphy (priest), Roman Catholic priest excommunicated in 1901
- William Murphy, Roman Catholic Bishop of Kerry, Ireland 91995 - )
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