Yuzpe regimen

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The Yuzpe Regimen is a method of emergency hormonal contraception using a combination of estrogen and progesterone hormones and started within 72 hours of sexual intercourse. It has subsequently been superseded by a progesterone-only hormonal regimen.

Contents

1 History
2 Description
3 Side effects
4 Formulations
5 References
6 External links

History

The method was first developed by a Canadian Professor A. Albert Yuzpe who published the first studies demonstrating the method's safety and efficacy in 1974.^{[#endnote_Yuzpe]}

Description

This [[wiktionary:regimen|regimen]] allows a woman who has had unprotected sex to avoid pregnancy by taking 12 hours apart two high-doses of estrogen and certain progestin hormones. The course needs to be started within 72 hours of sexual intercourse. In contrast, the licensing for emergency Intrauterine device (IUD) insertion allows for upto 5 days.

These hormones are usually administered either as a high number of regular-strength Combined Oral Contraceptive Pills (COCP), or as specific high-strength "Emergency contraceptive pills" (ECPs) (commonly known as "Morning-after pills"). Hence each dose can vary from 1 to 20 pills depending on the brand of medication being used. Patients concurrently taking certain regular medications (e.g. rifamycin and many anticonvulsant drugs) that enhance the liver's break down of other drugs, must use an even higher hormone dose and may be better advised to use as an alternative the insertion of an IUD.

The method is not guaranteed to prevent pregnancy and whilst the hormones may make the subsequent period come a few days early or late, a pregnancy test should be carried out if the period is more than 3 days late. The Yuzpe Regimen does not protect against sexually transmitted diseases.

Subsequently, the World Health Organization (WHO) undertook an investigation into the use of progesterone-only tablets as an Emergency Hormonal Contraceptive (i.e. without any estrogen component). This showed greater efficacy with reduced side effects^{[#endnote_WHO_EPOC]} and has therefore superseded the Yuzpe method.

Side effects

Some temporary, but usually minor, reactions include:

Nausea and/or vomiting
Breast tenderness
Irregular Bleeding
Headache or Dizziness

Should vomiting occur within 3 hours of taking a dose, then insufficient hormones may have been absorbed to provide the full contraceptive cover and an additional dose should be taken. Measures that may help to prevent nausea or vomiting include:

Take the pills with food.
Take Dramamine or Bonine an hour before taking the pills, if you are especially sensitive to or bothered by nausea -- however, this step is not necessary.
Schedule your doses so that you take the second dose before bed.

Formulations

Many common oral contraceptive pills could be used for the Yuzpe regimen^{[#endnote_PrincetonEC_dosages]}, although their manufacturers did not label the pills for this use. Such off-label use of approved medications is legal and commonplace in American medicine. Further, in February 1997, the United States Food and Drug Administration declared ECP use of birth control pills, following the Yuzpe regimen, as safe and effective.

The specific high-dose combined hormone formulations (Preven in US and Schering-PC4 in UK) are generally no longer available since the introduction of progesterone-only ECPs (Plan B in US and Levonelle one-step/Levonelle 1500 in UK).

References

↑ Yuzpe AA, Thurlow HJ, Ramzy I, Leyshon JI. Post coital contraception--A pilot study. J Reprod Med. 1974 Aug;13(2):53-8. PMID 4844513
↑ WHO Task Force on Postovulatory Methods of Fertility Regulation. Randomised controlled trial of levonorgestrel versus the Yuzpe regimen of combined oral contraceptives for emergency contraception. Lancet 1998;352:428-433. ([Abstract])
↑ Princeton University's Emergency Contraception Website (not-2-late.com) list of All information regarding pill brands and dosage was provided by [List of oral contraceptives that can be used for emergency contraception in the United States].

External links

General information on the Yuzpe Regimen was provided by [plannedparenthood.org].
A [biography of A. Albert Yuzpe] - Genesis Fertility Centre.

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